Invokamet is a new type-2 diabetes medication that has been linked to several life-threatening side effects, including ketoacidosis, kidney failure, bone fractures, amputations, and more.
Need a Texas Invokamet Lawyer? Collen A. Clark is a true advocate for his clients and is passionate about helping Texans that have been injured or wronged. If you or a loved one was diagnosed with a severe side effect, you should contact our lawyers immediately. You may be entitled to compensation by filing a lawsuit.
Invokamet Lawsuits Centralized in MDL
In December 2016, judges centralized nearly 100 lawsuits involving ketoacidosis, kidney failure, and other side effects of Invokana into Multi-District Litigation (MDL No. 2750) in the U.S. District Court for New Jersey under Judge Brian R. Martinotti. Lawyers requested the same venue in September.
What is Invokamet?
Invokamet is a type-2 diabetes medication that helps control blood-sugar levels with a combination of two drugs. One is metformin, which has been used successfully since the 1950s as a first-line treatment for type-2 diabetes. The other ingredient in Invokana is canagliflozin, which was introduced in 2013 and is sold alone under the brand-name Invokana. In September 2016, the FDA approved an extended-release version called Invokamet XR.
What is the problem?
Invokamet contains canagliflozin, the first FDA-approved drug in a new class of diabetes medications known as sodium-glucose cotransporter-2 (SGLT2) inhibitors. Because it is so new, the long-term safety data is limited. Unfortunately, it has already been linked to a number of severe, life-threatening side effects:
- Bone fractures
- Diabetic ketoacidosis
- Kidney infections
- Kidney failure
FDA Warnings for Diabetic Ketoacidosis
In December 2015, the FDA updated the label on all diabetes drugs in the SGLT2 inhibitor class to warn about ketoacidosis. The agency received 73 reports of the side effect between March 2013 and May 2015. Click here to read more.
Cses were unusual because ketoacidosis is normally associated with type-1 diabetes rather than type-2. The agency warns patients to seek medical attention they develop any symptoms of ketoacidosis:
“Pay close attention for any signs or symptoms of acidosis such as difficulty breathing, nausea, vomiting, abdominal pain, confusion, and unusual fatigue or sleepiness. Seek medical attention immediately if you experience any of these symptoms.”
FDA Strengthens Kidney Injury Warnings
In June 2016, the FDA issued a Safety Communication to strengthen warnings about the risk of acute kidney injury from Invokamet. The agency received over 100 confirmed reports. Risk-factors include common medications like diuretics, blood pressure drugs (ARBs and ACE inhibitors), and painkillers like ibuprofen. Click here to read more.
Study Finds Doubled Risk of Amputations
In May 2016, the FDA warned about studies linking Invokamet with a doubled increased risk of lower-limb amputations, mostly toe amputations. The problem is that one of the most common side effects of Invokamet is dehydration, which can cause poor circulation in the feet.
FDA Requires “Black Box” Amputation Warning
In May 2017, the FDA ordered drug-makers to update the label on Invokana with a “Black Box” warning about the risk of toe, leg, and foot amputations. The risk of amputation is estimated at 7 in 1,000 patients on Invokana, which is twice the risk of amputation in diabetics who do not take Invokana. Toe and middle-foot amputations were most common, but there were also reports of patients who needed amputations above and below the knee. Some people needed multiple amputations, or had both legs amputated.
What is Diabetic Ketoacidosis?
Diabetic ketoacidosis (ketosis) occurs when the body cannot use glucose (sugar) in the blood because it does not have enough insulin. Instead, the body starts burning fat as a fuel source, which releases acidic wastes known as ketones. Without treatment, a victim can lapse into a diabetic coma and die.
Symptoms of Ketoacidosis
- Feeling very thirsty or dry mouth for at least a day
- Frequent urination
- High blood-sugar (hyperglycemia)
- High ketones in urine
- Feeling tired and less alert
- Deep, rapid breathing or trouble breathing
- Dry skin
- Flushed face
- Fruity-smelling breath
- Nausea, vomiting
- Abdominal or stomach pain
Invokamet Class Action Lawsuit
The Clark Firm, LLP is nationally recognized as a class action law firm in Texas. However, instead of filing an Invokamet class action, our Texas trial attorneys are filing individual lawsuits. We are only accepting cases involving individuals who were severely injured by side effects of Invokamet.
Need an Invokamet Lawyer in Texas?
Collen A. Clark is a true advocate for his clients and is passionate about helping Texans that have been injured or wronged.
Collen’s amazing success in the courtroom and well known dedication to his clients has earned him the recognition of his peers as one of The Top Trial Lawyers in Texas.”
The Clark Firm has assembled a team of trial lawyers with more than 100 years experience, participation in over 600 jury trials and $260 million in verdicts and/or settlements. Please use the form below to contact our Texas Invokamet lawyers for a free lawsuit review.