Uloric (febuxostat) is a gout medication manufactured by Takeda Pharmaceuticals. Takeda is facing a growing number of lawsuits alleging that they did not warn about the risk of major side effects. Our lawyers are now evaluating potential Uloric lawsuits on behalf of people who were seriously injured by this drug.

What is Uloric?

When the U.S. Food and Drug Administration (FDA) approved Uloric (febuxostat) in February 2009, it was hailed as the first new gout drug in over 40 years. It works by inhibiting an enzyme called xanthine oxidase, which the body needs to create uric acid. This reduces uric acid levels, which treats painful joint inflammation in gout users.

Uloric Lawsuit Information

In 2012, Takeda Pharmaceuticals was hit with two whistleblower lawsuits filed by Helen Ge, a former safety consultant who alleged that the company was not reporting severe side effects of Uloric and Actos (pioglitazone), including bladder cancer, bone marrow failure, and more. Takeda is now facing thousands of lawsuits from people who were injured by these severe side effects. These lawsuits are not centralized in a Uloric class action — instead, they are individual claims filed by people with severe injuries.

Your Uloric lawsuit could receive compensation for:

  • Pain and suffering
  • Medical expenses
  • Lost income, employment
  • Permanent injury or disability
  • Punitive damages

FDA Safety Warnings for Uloric Side Effects

The FDA Warnings and Precautions for Uloric were updated in January 2011 and November 2012. The Prescribing Information (PDF) has been updated to include a wide range of side effects, including:

  • Nausea
  • Liver failure
  • Kidney damage
  • Rhabdomyolysis
  • Heart attack
  • Stroke
  • Rash
  • Immune system disorders
  • Allergic reaction (anaphylaxis, rash, Stevens Johnson Syndrome)
  • Psychiatric disorders (psychotic behavior, aggressive thoughts)
  • Kidney and urinary disorders
  • Bone marrow failure
  • Severe bleeding
  • And more

Uloric and Liver Failure

Liver failure is one of the most severe side effects of Uloric, which is why patients should have periodic blood tests to check liver function. During clinical trials, elevated liver enzyme levels were one of the most common side effects, estimated to occur in 4-6% of users. Levels returned to normal after Uloric was discontinued. About 2% of Uloric patients had elevated liver enzymes 3-times the upper-limit of normal.

Symptoms of liver damage from Uloric:

  • Abdominal pain and discomfort (upper-right side)
  • Nausea, vomiting
  • Jaundice (yellowing of the skin and whites of the eyes)
  • Fatigue
  • Malaise (generally feeling unwell)
  • Confusion, disorientation
  • Changes in personality or behavior

Uloric and Rhabdomyolysis

In January 2011, the side effect information for Uloric was updated to include rhabdomyolysis. This is a life-threatening disease that occurs when muscle fibers break down, release myoglobin in the bloodstream. When the kidneys filter myoglobin, it clogs small blood vessels and causes kidney damage.

Symptoms of rhabdomyolysis from Uloric:

  • Dark-colored urine
  • Decreased production of urine
  • Muscle stiffness, weakness, tenderness, or aching
  • Joint pain
  • Fatigue


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