Jentadueto is a prescription medication that is prescribed to help lower blood-sugar levels in adults with type-2 diabetes. Jentadueto belongs to a new class of drugs that treat diabetes by influencing metabolic hormones. Unfortunately, recent studies suggest that this may increase a patient’s risk of pancreatitis or pancreatic cancer.
Do I Have a Texas Jentadueto Lawsuit? Collen A. Clark is a true advocate for his clients and is passionate about helping Texans that have been injured or wronged. If you or a loved one was diagnosed with pancreatic cancer, you should contact our lawyers immediately. You may be entitled to compensation by filing a lawsuit.
Jentadueto Side Effects
UPDATE: FDA Safety Warning for Jentadueto and Cancer
What is Jentadueto?
Jentadueto (linagliptin / metformin) is a single-tablet, twice-daily medication to help patients with type-2 diabetes control their blood-sugar levels. It was created by Boehringer Ingelheim and approved by the U.S. Food and Drug Administration (FDA) in January 2012.
Jentadueto combines metformin (an anti-diabetes drug that has been used for decades) with a new drug called linagliptin (sold alone under the brand-name Tradjenta). Linagliptin treats diabetes by inhibiting dipeptidyl-peptidase-4 (DPP-4), which results in extended longevity of a hormone called glucagon-like peptide-1 (GLP-1). GLP-1 causes significant proliferation of beta-cells in the pancreas, which produce more insulin and lower blood-sugar levels.
What is the problem with Jentadueto?
Jentadueto belongs to a new class of drugs called incretin mimetics, which mimic metabolic hormones (incretins, such as GLP-1) to treat type-2 diabetes. This class of drugs has only been sold since Januvia (sitagliptin) was marketed by Merck in 2006. Since Jentadueto and other incretin mimetic drugs are so new, there is limited information regarding long-term side effects. Unfortunately, there is a growing amount of research linking Jentadueto to a potential risk of pancreatitis, pancreatic cancer, and thyroid cancer.
FDA Investigates Study Linking Jentadueto and Pancreatic Cancer
In 2009, the FDA asked the manufacturers of incretin therapy diabetes drugs to “explore a potential signal of a serious risk of thyroid cancer and pancreatic cancer.” In March 2013, the FDA announced that they were investigating a link between Jentadueto and pancreatic cancer after a concerning study was published in Diabetes.
For the study, researchers autopsied the pancreases of eight patients who had been using a drug in the incretin mimetic class to treat diabetes. These pancreases were compared to pancreases from diabetics who were using other drugs and people who did not have diabetes.
The researchers found that the incretin mimetic group of pancreases were 40% larger, had six times as many beta-cells, and there was alarming evidence of pancreatitis (chronic inflammation) and “eccentric” pre-cancerous cell growth. Furthermore, three pancreases in the incretin mimetic group had pancreatic tumors called adenomas, which normally must be surgically removed because they can become malignant and cause pancreatic cancer.
Jentadueto Class Action
The Clark Firm, LLP is nationally recognized as a class action law firm, but we are not filing a Jentadueto class action. Instead, we are pursuing individual lawsuits against drug-makers for failing to warn about side effects.
As of January 2016, over 750 lawsuits involving pancreatic side effects of incretin therapy diabetes medications were centralized in a Multi-District Litigation (MDL No. 2452) in federal court in California, In Re: Incretin Mimetics Products Liability Litigation.
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