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Safyral is a once-daily hormonal contraceptive that combines two synthetic hormones (drospirenone and ethinyl estradiol) with a folate B-vitamin. One severe side effect of Safyral is gallbladder disease and gallstones. The gallbladder can become severely inflamed and damaged by gallstones. Around half of people with gallbladder disease require surgery to remove the gallbladder.

Safyral Overview

Safyral is a hormonal contraceptive that is essentially Yasmin plus a folate dietary supplement. Safyral and Yasmin each contain the same combination of hormones — drospirenone (synthetic progestin) and ethinyl estradiol (synthetic estrogen). Safyral also contains 0.451-mg levomefolate calcium, a folic acid B-vitamin.

Safyral contains folate to prevent neural tube birth defects, when Safyral fails to prevent pregnancy. Although Safyral is more than 99% effective at preventing pregnancy when taken exactly as directed (one pill, every day, at the same time every day), a lot of women don’t take birth control pills consistently. For these women, pregnancy occurs in approximately 9 per 100 women.

Experts know that pre-pregnancy folate deficiencies are responsible for most neural tube birth defects. These birth defects include spina bifida, anencephaly, iniencephaly, and more.

Safyral Gallbladder Disease

Compared to men, women are twice as likely to get gallstones and suffer from gallbladder disease. Experts know that this is due to the fact that women ingest hormonal contraceptives and use hormone replacement therapy. Women may also suffer from gallbladder disease after pregnancy, due to elevated estrogen levels.

High levels of hormones may increase the risk of gallbladder disease in several ways. One is increasing the amount of calcified cholesterol that enters the gallbladder, which can form gallstones. Another way would be decreasing the movement of bile from the gallbladder. Safyral may also increase the risk of gallbladder disease by acting as a diuretic.

What is Gallbladder Disease?

Gallbladder disease occurs when the gallbladder (a digestive organ) becomes severely inflamed. Inflammation of the gallbladder is called a gallbladder attack, and these painful, debilitating attacks can occur for several minutes or several hours. The pain may be most intense at night or after eating a fatty meal.

Gallstones can develop in the gallbladder and cause gallbladder disease. Gallstones are comprised of calcified particulate matter that coalesces into small, hard “stones.” These stones may be the size of a grain of sand or a golfball. Sometimes, several large gallstones fill the gallbladder and cause the organ to be severely damaged.

Around half of people with gallbladder disease need to have their gallbladder removed. Fortunately, the gallbladder is not necessary for survival. Surgery to remove the gallbladder is called a cholecystectomy.

Signs & Symptoms of Gallbladder Disease

Safyral gallbladder disease may be not be diagnosed immediately when problems occur, and they may be mistaken for indigestion or other digestive problems. Many women who suffer from Safyral gallbladder disease are young, have no risk factors, and have no history of gallbladder disease. The illness is typically diagnosed after it starts causing prolonged, severe pain and other side effects.

Symptoms of Safyral gallbladder disease include:

  • Pain in the upper abdomen, usually located just under the ribcage on the right side of the body
  • Pain may last for minutes or hours. It may occur at night or after eating a fatty meal.
  • Nausea, vomiting
  • Indigestion
  • Gas, bloating
  • Burping, belching

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