Recent studies have found that patients who take Nexium every day are 20-50% more likely to develop chronic kidney disease, a serious side effect that can lead to kidney failure or even death. In 2014, the FDA updated the label on Nexium to include kidney inflammation (nephritis).

Need a Texas Nexium Lawyer? Collen A. Clark is a true advocate for his clients and is passionate about helping Texans that have been injured or wronged. If you or a loved one was diagnosed with kidney failure, renal disease, or nephritis, you should contact our lawyers immediately. You may be entitled to compensation by filing a lawsuit.

UPDATE: Nexium Lawsuits Centralized in MDL

August 2017 — Judges have centralized 161 lawsuits involving kidney injuries from Nexium and other PPI heartburn drugs into Multi-District Litigation (MDL No. 2798) under Judge Claire C. Cecchi in the District of New Jersey — In RE: Proton-Pump Inhibitor Products Liability Litigation (No. II). Drug-makers are accused of failing to warn that Nexium can cause kidney injuries, Chronic Kidney Disease (CKD), acute interstitial nephritis, end-stage kidney disease, or kidney failure.

Study Links Heartburn Drugs and Death

July 2017 — A new study published in BMJ Open has found up to a 50% increased risk of death for people who use PPI heartburn drugs for 1-2 years instead of another type of heartburn drugs called H2-blockers. long-term use of PPI heartburn drug. Click here to read more.

Heartburn Drugs Causing Massive Health Problems

Nexium Lawsuits

July 5, 2016 — A lawsuit (PDF) has been filed by a man from Tennessee who developed severe kidney problems (nephritis) and needed dialysis after taking Nexium. The lawsuit was filed against AstraZeneca in the U.S. District Court for the Western District of Tennessee — Case No. 2:16-cv-02549. Click here to read more.

Study Links Nexium and 96% Higher Risk of Kidney Failure

April 2016 — A study published in the Journal of the American Society of Nephrology has linked the use of anti-heartburn medications in the PPI class to a 96% increased risk of kidney failure and a 26% increased risk of chronic kidney disease. Click here to read more.


Nexium belongs to a group of drugs known as proton pump inhibitors (PPIs), which work by reducing the amount of acid in the stomach in order to treat acid reflux disease and common heartburn conditions. PPIs are available over-the-counter and by prescription.

Nexium may also be used to treat gastroesophageal reflux disease (GERD or acid reflux disease), a condition where the backward flow of acid from the stomach causes heartburn and possible injury to the throat. It is also used to prevent gastic ulcers and in treatment of conditions involving excessive stomach acid, such as Zollinger-Ellison syndrome.

Nexium and Nephritis

Evidence linking Nexium and nephritis (sudden kidney inflammation) has been growing since the early 1990s when the first case reports were published. Another 15 cases were reported by AstraZeneca in 2004. Dozens of cases have been reported worldwide, including some reports in which older patients needed long-term dialysis for kidney failure.

FDA Adds Nephritis to Nexium Label

In December 2014, the FDA updated the label on Nexium to include stronger warnings about acute interstitial nephritis (sudden kidney inflammation). According to the FDA, nephritis is caused by an allergic reaction and it can occur at any time while taking Nexium. Without treatment, nephritis can cause kidney failure.

Study Links Nexium and 20-50% Increased Risk of Kidney Disease

In January 2016, researchers at Johns Hopkins University published a study linking the use of Nexium with a 20-50% increased risk of Chronic Kidney Disease (CKD). Researchers found that people who used heartburn medications twice a day had the highest risk. Conclusions of the study were based on data from 10,500 patients between 1996 and 2015.

Nephritis and Kidney Injury

In April 2015, the Canadian Medical Association published a study linking long-term treatment with PPIs to a tripled increased risk of nephritis and a 2.4-fold increased risk of acute kidney injury. The researchers based their conclusions on data from 290,000 adults over 66 years old in Ontario who started taking PPIs between 2002 and 2011.

Kidney Side Effects

Bone Fractures

In May 2010, the FDA found Nexium and PPIs may cause a possible increased risk of fractures of the hip, wrist and spine — especially in older patients who have used it for a year or more and/or at high, prescription-level doses.The FDA concluded that short-term, low dose PPI use is unlikely to result in osteoporosis or bone fracture.

Of seven studies reviewed by the FDA, six reported an increased risk of hip, wrist and spine fractures with the use of PPIs. The emergence of fractures varies among studies with one study reporting an increase in fractures after just one year of use, while another study found an increase after 5 to 7 years of PPI use.

Bone Fracture Lawsuits Centralized in MDL

In December 2012, nearly 40 Nexium bone fracture lawsuits and class-actions have been centralized in the U.S. District Court for the Central District of California before Judge Dale S. Fisher.

Study Links Nexium and 35% Increased Risk of Bone Fractures

In January 2012, a study published in the British Medical Journal found a link between Nexium and bone fractures. The risk of hip fractures was 35% higher for post-menopausal women who took Nexium or other PPI heartburn drugs regularly for at least two years. Women who smoked had an even higher risk.

Side Effects

Some of the most serious side effects of Nexium include:

  • Chronic Kidney Disease (CKD)
  • Nephritis
  • Kidney failure
  • Bone fractures
  • Low magnesium levels
  • Tetany (muscle spasm)
  • Infections
  • Arrhythmia and heart problems
  • Seizures

FDA Updates Warning Labels on Nexium

In November 2014, the FDA added new warnings about side effects of Nexium, but they did not add a “Black Box” warning about bone fractures and pneumonia. New warnings added to the label include:

  • Clostridium difficile-associated diarrhea
  • Vitamin B12 deficiency
  • Acute interstitial nephritis
  • Recommended treatment length for gastroesophageal reflux disease (GERD)
  • Drug interactions with methotrexate (a cancer drug that can remain in the body and become toxic) and mycophenolate mofetil
  • Drug interactions with Plavix (clopidogrel), a blood-thinner that may be less effective in patients on heartburn drugs

Low Magnesium Levels

In March 2011, the FDA issued a Drug Safety Communication suggesting Nexium and other drugs belonging to the PPI group may cause hypomagnesemia, characterized by low serum magnesium levels, if taken for a prolonged period — usually over one year, but some cases developed after only 3 months. The FDA has identified at least 50 cases of hypomagnesemia, likely caused by heartburn medications like Nexium.

Hypomagnesemia may be serious because it can lead to tetany (muscle spasms), irregular heartbeats, fast heartbeat, seizures, tremors, chest pain, and dark urine. Hypomagnesemia may be difficult to treat, even with the use of magnesium supplements. Some patients needed to be taken off of their PPI medication for their magnesium levels to return to normal.

Need a Nexium Lawyer in Texas?

Collen A. Clark is a true advocate for his clients and is passionate about helping Texans that have been injured or wronged.

Collen’s amazing success in the courtroom and well known dedication to his clients has earned him the recognition of his peers as one of The Top Trial Lawyers in Texas.”

The Clark Firm has assembled a team of trial lawyers with more than 100 years experience, participation in over 600 jury trials and $260 million in verdicts and/or settlements. Please use the form below to contact our Texas Nexium lawyers for a free lawsuit review.

Meet Your Attorney

Collen A. Clark

Collen A. Clark is a true advocate for his clients and is passionate about helping Texans that have been injured or wronged.

“Collen’s amazing success in the courtroom and well known dedication to his clients has earned him the recognition of his peers as one of The Top Trial Lawyers in Texas.”

To contact Collen, please fill out the contact form below:

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