Janumet XR is a new type-2 diabetes drug that is linked to pancreatitis, pancreatic cancer, rhabdomyolysis, and other severe side effects.
Need a Texas Janumet XR Lawyer? Collen A. Clark is a true advocate for his clients and is passionate about helping Texans that have been injured or wronged. If you or a loved one was diagnosed with pancreatic cancer, you should contact our lawyers immediately. You may be entitled to compensation by filing a lawsuit in Texas.
Janumet XR Side Effects
- Bile duct disease
- Bullous pemphigoid
- Gallbladder disease
- Heart failure
- Joint pain
- Pancreatic cancer
FDA Evaluating Rhabdomyolysis Risk
The FDA is evaluating a potential signals of a serious risk and new safety information linking DPP4 diabetes drugs and rhabdomyolysis. This potentially life-threatening kidney side effect was identified by the FDA Adverse Event Reporting System (FAERS) between April and June 2017.
Janumet XR Linked to Severe Joint Pain
How Does Sitagliptin Treat Type-2 Diabetes?
Janumet XR contains sitagliptin is a new drug in a new class of drugs called “incretin mimetics.” These drugs work by mimicking incretins (digestive hormones that regulate insulin and blood-sugar levels). Sitagliptin works by inhibiting an enzyme called DPP-4 (dipeptidyl peptidase-4). Normally, DPP-4 breaks down an incretin hormone called GLP-1 (glucagon-like peptide-1). Without DPP-4, more GLP-1 stimulates the pancreas to make more insulin, which lowers blood-sugar.
Janumet XR and Pancreatitis
Sitagliptin works by directly targeting cells in the pancreas to make more insulin. Many experts are concerned that this could lead to inflammation in the pancreas (pancreatitis). In August 2009, the FDA issued a Drug Safety Communication to report 88 cases of acute, hemorrhagic and necrotizing pancreatitis in patients on sitagliptin.
Janumet XR and Pancreatic Cancer
Chronic pancreatitis is a major risk-factor for pancreatic cancer. In March 2013, the FDA issued a Drug Safety Communication after reviewing evidence linking sitagliptin and pre-cancerous pancreatic growths. The study, published in the journal Diabetes, found evidence that exposure to sitagliptin could cause excessive cell proliferation in the pancreas. Autopsies showed that pancreases were ~40% larger than normal, with 6-times as many beta-cells. Three pancreases had micro-adenomas, and one pancreas had a neuroendocrine tumor.
Need a Janumet XR Lawyer in Texas?
Collen A. Clark is a true advocate for his clients and is passionate about helping Texans that have been injured or wronged.
Collen’s amazing success in the courtroom and well known dedication to his clients has earned him the recognition of his peers as one of The Top Trial Lawyers in Texas.”
The Clark Firm has assembled a team of trial lawyers with more than 100 years experience, participation in over 600 jury trials and $260 million in verdicts and/or settlements. Please use the form below to contact our Texas Janumet XR lawyers for a free lawsuit review.