Cialis Skin Cancer Lawsuits Centralized in MDL

Cialis MDLDecember 14, 2016 — Lawsuits involving men who developed melanoma (skin cancer) after taking Cialis have been centralized into one federal court in California.

In an order (PDF) on December 7, the U.S. Judicial Panel on Multi-District Litigation (JPML) centralized 10 Cialis lawsuits against Eli Lilly & Co.

The lawsuits will be sent to the U.S. District Court for the Northern District of California under Judge Richard Seeborg, where over 200 Viagra melanoma lawsuits were already centralized against Pfizer.

The JPML decided to expand the scope of the Viagra Multi-District Litigation (MDL No. 2691) rather than create a new one for Cialis.

All of the lawsuits claim that treating erectile dysfunction by blocking the enzyme PDE5 can cause melanoma or make it more aggressive.

Viagra and Cialis both work by blocking the enzyme PDE5, which increases blood-flow to the penis by relaxing blood vessels. The problem is that about 50% of melanomas also inhibit PDE5, and studies have shown that these cancers become more invasive.

The first study correlating PDE5 inhibitors and melanoma was published in 2008. In 2011, another study associated a “dramatic increase in melanoma cell invasion” with PDE5 inhibition.

In 2014, researchers at Harvard University found an 84% increased risk of melanoma in a study of 25,000 men who had recently used PDE5-inhibitor medications for the treatment of erectile dysfunction.

The FDA is currently investigating. Melanoma is the most dangerous type of skin cancer. It is more aggressive, spreads more quickly in the body, and more likely to cause death. The cancer resembles a mole in its early stages, which can delay diagnosis until it is impossible to cure.

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