Invokana is associated with metabolic acidosis, a condition where there is too much acid in the body. The risk increases in patients who develop severe infections or dehydration, which are common side effects of Invokana.
Need a Texas Invokana Lawyer? Collen A. Clark is a true advocate for his clients and is passionate about helping Texans that have been injured or wronged. If you or a loved one was diagnosed with metabolic acidosis, you should contact our lawyers immediately. You may be entitled to compensation by filing a lawsuit.
Invokana and Metabolic Acidosis
In May 2015, the FDA issued a Safety Communication to warn about the risk of metabolic acidosis in patients on Invokana. According to the FDA:
“Patients should pay close attention for any signs of ketoacidosis and seek medical attention immediately if they experience symptoms such as difficulty breathing, nausea, vomiting, abdominal pain, confusion, and unusual fatigue or sleepiness.”
What is the problem?
Invokana treats diabetes by forcing the kidneys to remove more sugar from the body in urine. This significantly increases the risk of infections and dehydration — two major risk-factors for metabolic acidosis. Other risk-factors for acidosis include:
- Emotional or physical stress
- Illness or fever
- Surgery or trauma
- Eating or drinking less than normal
- Drinking alcohol often or a lot at once
- Missed dose of insulin
Report Links Invokana and 168 Cases of Metabolic Acidosis
In January 2016, the Institute for Safe Medication Practices (ISMP) published a report (PDF) identifying 168 possible cases of metabolic acidosis associated with Invokana in the last 12 months.
What is Metabolic Acidosis?
Metabolic acidosis occurs when there is too much acid in body fluids. It can occur when the kidneys stop removing acid from the body or the body produces too much acid.
Types of Metabolic Acidosis
- Diabetic ketoacidosis
- Hyperchloremic acidosis
- Lactic acidosis
Diabetic ketoacidosis (DKA) is a type of metabolic acidosis that can occur in people with type-1 or type-2 diabetes. When people with diabetes do not have enough insulin, the body starts breaking down fat and muscle cells for energy. This releases ketones, which are acids that accumulate in the blood and cause acidosis.
Invokana contains canagliflozin. It is usually taken in combination with other diabetes drugs. Some patients take Invokamet, which combines canagliflozin and metformin. The label on metformin has a “Black Box” warning about lactic acidosis, especially in patients with kidney or liver problems.
Complications of Metabolic Acidosis
Some of the most serious complications include cerebral edema (swelling in the brain), heart attack, blood clots, low blood pressure, tissue damage, kidney failure, and coma. About 1-5% of cases are deadly.
Treatment for Metabolic Acidosis
Metabolic acidosis is a life-threatening medical condition that must be treated in a hospital. Patients will receive intravenous (IV) fluids and medications like insulin or bicarbonate (baking soda) supplements to balance the pH of their blood.
Need an Invokana Lawyer in Texas?
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The Clark Firm has assembled a team of trial lawyers with more than 100 years experience, participation in over 600 jury trials and $260 million in verdicts and/or settlements. Please use the form below to contact our Texas Invokana lawyers for a free lawsuit review.