Risperdal Gynecomastia Risk 69% Higher for Older Men

March 18, 2014 — Researchers from the University of British Columbia have presented data from a new study linking Risperdal (risperidone) and gynecomastia (male breast enlargement) in older men, according to Medscape.

Researchers found that men on Risperdal were 69% more likely to develop gynecomastia than men who did not use Risperdal. Gynecomastia was also 41% more likely to occur in men on Seroquel (quetiapine) and 40% more likely to occur in men on Zyprexa (olanzapine).

The median age of men in the study was 65.5 years, which suggests that gynecomastia is a side effect of Risperdal in men of any age.

Conclusions were based on data from more than 1 million men in the United States between the ages of 45 and 80 years old. Researchers analyzed health claims from the IMS LifeLink Health Plan between 2001 and 2011. During this time, there were 8,285 cases of gynecomastia.

The data was presented on March 15 at a conference for the American Association for Geriatric Psychiatry (AAGP). The study is currently being reviewed for publication in a peer-reviewed journal.

Johnson & Johnson, the manufacturer of Risperdal, is now facing hundreds of lawsuits involving gynecomastia and other side effects. Many of these lawsuits involve young men who were prescribed Risperdal as children — before it was ever approved for pediatric uses. Last year, J&J agreed to pay $2.2 billion to resolve civil and criminal allegations that they improperly marketed Risperdal.

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